Research Papers On:
Ph.D. Dissertations:
Nuclear protein quality control
JCS coverGallagher, P. S., Clowes Candadai, S. V., and R. G. Gardner. 2014.
The requirement for Cdc48/p97 in nuclear protein quality control degradation depends on the substrate and correlates with substrate insolubility.
Journal of Cell Science 127:1980-1991.
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CMLS coverGallagher, P. S., Oeser, M. L., Ayelet-chen, A., Kaganovich, D., and R. G. Gardner. 2014.
Cellular maintenance of nuclear protein homeostasis.
Cellular and Molecular Life Sciences 71:1865-1879.
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JBC coverFredrickson, E. K., Clowes Candadai, S. V., Tam, C. H., and R. G. Gardner. 2013.
Means of self-preservation: how an intrinsically disordered ubiquitin-protein ligase averts self-destruction.
Molecular Biology of the Cell 24:1041-1052.
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JBC coverFredrickson, E. K., Gallagher, P. S., Clowes Candadai, S. V., and R. G. Gardner. 2013.
Substrate Recognition in Nuclear Protein Quality Control Degradation Is Governed by Exposed Hydrophobicity That Correlates with Aggregation and Insolubility.
The Journal of Biological Chemistry 288:6130-6139.
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SCDB coverFredrickson, E. K. and R. G. Gardner. 2012.
Selective destruction of abnormal proteins by ubiquitin-mediated protein quality control degradation.
Seminars in Cell & Developmental Biology 23:530-537.
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MBoC coverFredrickson, E. K., Rosenbaum, J. C., Locke, M. N., Milac, T. I., and R. G. Gardner. 2011.
Exposed hydrophobicity is a key determinant of nuclear quality control degradation.
Molecular Biology of the Cell 22:2384-2395.
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Nucleus coverRosenbaum, J. C. and R. G. Gardner. 2011.
How a disordered ubiquitin ligase maintains order in nuclear protein homeostasis.
Nucleus 2:264-270.
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Molecular Cell coverRosenbaum, J. C., Fredrickson, E. K., Oeser, M. L., Garrett-Engele, C. M., Locke, M. N., Richardson, L. A., Nelson, Z. W., Hetrick, E. D., Milac, T. I., Gottschling, D. E., and R. G. Gardner. 2011.
Disorder Targets Misorder in Nuclear Quality Control Degradation: A Disordered Ubiquitin Ligase Directly Recognizes Its Misfolded Substrates.
Molecular Cell 41:93-106.
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JCB coverWilliams R. 2008.
Richard Gardner: Nuclear garbologist
Journal of Cell Biology 181:6-7.
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Cell coverGardner, R. G., Nelson, Z. W., and D. E. Gottschling. 2005.
Degradation-mediated protein quality control in the nucleus.
Cell 120:803-815.
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Protein Aggregation
Molecular Cell coverKonopka, C. A., Locke, M. N., Gallagher, P. S., Pham, N., Hart, M. P., Walker, C. J., Gitler, A. D., and R. G. Gardner. 2011.
A yeast model for polyalanine-expansion aggregation and toxicity.
Molecular Biology of the Cell 22:1971-1984.
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Chromatin regulation
CR coverRichardson, L. A., Reed, B. J., Charette, J. M., Freed, E. F., Fredrickson, E. K., Locke, M. N., Baserga, S. J., R. G. Gardner. 2012.
A Conserved Deubiquitinating Enzyme Controls Cell Growth by Regulating RNA Polymerase I Stability.
Cell Reports 2:372-385.
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MCB coverGardner, R. G., Nelson, Z. W., and D. E. Gottschling. 2005.
Ubp10/Dot4p Regulates the Persistence of Ubiquitinated Histone H2B: Distinct Roles in Telomeric Silencing and General Chromatin.
Molecular and Cellular Biology 25:6123-6139.
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ER protein quality control and sterol regulation
MCB coverGardner, R. G., Shearer, A. G., and R. Y. Hampton. 2001.
In Vivo Action of the HRD Ubiquitin Ligase Complex: Mechanisms of Endoplasmic Reticulum QualityControl and Sterol Regulation.
Molecular and Cellular Biology 21: 4276-4291.
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JBC coverGardner, R. G., Shan, H., Matsuda, S. P. T., and R. Y. Hampton. 2001.
An oxysterol-derived positive signal for 3-hydroxy-3-methylglutaryl-CoA reductase degradation in yeast.
Journal of Biological Chemistry 276: 8681-8684.
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NCB coverBays, N. W., Gardner, R. G., Seelig, L. P., Joazeiro, C. A., and R. Y. Hampton. 2001.
Hrd1p/Der3p is a membrane-anchored ubiquitin ligase required for ER-associated degradation.
Nature Cell Biology 3:24-29.
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JCB coverGardner, R. G., Swarbrick, G. M., Bays, N. W., Cronin, S. R., Wilhovsky, S., Seelig, L., Kim, C., and R. Y. Hampton. 2000.
Endoplasmic reticulum degradation requires lumen to cytosol signaling: transmembrane control of Hrd1p by Hrd3p.
Journal of Cell Biology 151:69-82.
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MBoC coverWilhovsky, S., Gardner, R., and R. Hampton. 2000.
HRD gene dependence of endoplasmic reticulum degradation.
Molecular Biology of the Cell 11:1697-1708.
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EMBO coverGardner, R. G. and R. Y. Hampton. 1999.
A 'distributed degron' allows regulated entry into the ER degradation pathway.
The Embo Journal 18:5994-6004.
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JBC coverGardner, R. G. and R. Y. Hampton. 1999.
A highly conserved signal controls degradation of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase in eukaryotes.
Journal of Biological Chemistry 274:31671-31678.
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MBoC coverGardner, R., Cronin, S., Leader, B., Rine, J., and R. Hampton. 1998.
Sequence determinants for regulated degradation of yeast 3-hydroxy-3-methylglutaryl-CoA reductase, an integral endoplasmic reticulum membrane protein.
Molecular Biology of the Cell 9:2611-2626.
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MBoC coverHampton, R. Y., Gardner, R. G., and J. Rine. 1996.
Role of 26S proteasome and HRD genes in the degradation of 3-hydroxy-3-methylglutaryl-CoA reductase, an integral endoplasmic reticulum membrane protein.
Molecular Biology of the Cell 7:2029-2044.
Abstract
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Ph.d. dissertations
PhD coverGardner, R. G. 2000.
A mechanistic characterization of the regulated degradation of the yeast 3-hydroxy-3-methylglutaryl coenzyme A reductase, Hmg2p.
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