PUBLICATIONS

Nuclear Armageddon

Proteins govern nuclear functions. If they lose their structures, the nucleus can become critical. We are interested in how the cell protects against protein misfolding armageddon...

Gallagher, P. S., Clowes Candadai, S. V., and R. G. Gardner. 2014.

The requirement for Cdc48/p97 in nuclear protein quality control degradation depends on the substrate and correlates with substrate insolubility.

Journal of Cell Science 127:1980-1991.

 

Abstract

PDF (7.7M)

 

Gallagher, P. S., Oeser, M. L., Ayelet-chen, A., Kaganovich, D., and R. G. Gardner. 2014.

Cellular maintenance of nuclear protein homeostasis.

Cellular and Molecular Life Sciences 71:1865-1879.

 

Abstract

PDF (596K)

 

Fredrickson, E. K., Clowes Candadai, S. V., Tam, C. H., and R. G. Gardner. 2013.

Means of self-preservation: how an intrinsically disordered ubiquitin-protein ligase averts self-destruction.

Molecular Biology of the Cell 24:1041-1052.

 

 

Fredrickson, E. K., Gallagher, P. S., Clowes Candadai, S. V., and R. G. Gardner. 2013.

Substrate Recognition in Nuclear Protein Quality Control Degradation Is Governed by Exposed Hydrophobicity That Correlates with Aggregation and Insolubility.

The Journal of Biological Chemistry 288:6130-6139.

 

Abstract

PDF (2.1M)

 

 

Fredrickson, E. K. and R. G. Gardner. 2012.

Selective destruction of abnormal proteins by ubiquitin-mediated protein quality control degradation.

Seminars in Cell & Developmental Biology 23:530-537.

 

Abstract

PDF (548K)

 

 

Fredrickson, E. K., Rosenbaum, J. C., Locke, M. N., Milac, T. I., and R. G. Gardner. 2011.

Exposed hydrophobicity is a key determinant of nuclear quality control degradation.

Molecular Biology of the Cell 22:2384-2395.

 

Abstract

PDF (2.9M)

 

Rosenbaum, J. C. and R. G. Gardner. 2011.

How a disordered ubiquitin ligase maintains order in nuclear protein homeostasis.

Nucleus 2:264-270.

 

Abstract

PDF (2.0M)

Rosenbaum, J. C., Fredrickson, E. K., Oeser, M. L., Garrett-Engele, C. M., Locke, M. N., Richardson, L. A., Nelson, Z. W., Hetrick, E. D., Milac, T. I., Gottschling, D. E., and R. G. Gardner. 2011.

Disorder Targets Misorder in Nuclear Quality Control Degradation: A Disordered Ubiquitin Ligase Directly Recognizes Its Misfolded Substrates.

Molecular Cell 41:93-106.

Abstract

PDF (3.1M)

Highlighted in a Preview in same issue.

 

Williams R. 2008.

Richard Gardner: Nuclear garbologist

Journal of Cell Biology 181:6-7.

 

PDF (496K)

 

Gardner, R. G., Nelson, Z. W., and D. E. Gottschling. 2005.

Degradation-mediated protein quality control in the nucleus.

Cell 120:803-815.

 

Abstract

PDF (580K)

Highlighted in a Preview in same issue.

More to come.

 

RESEARCH

A conserved deubiquitinating enzyme uses intrinsic disordered regions to scaffold multiple protein-interaction sites. JBC 290: 20601-20612.

Dynamic sumoylation of a conserved transcription corepressor prevents persistent inclusion formation during hyperosmotic stress. PLoS Genetics 12: e1005809.

OUR FUNDING

© 2020  Gardner Lab. All Rights Reserved

Richard Gardner

Department of Pharmacology

Box 357280

University of Washington

Seattle, WA 98195-7280