PUBLICATIONS

The Traffic Jam of Ribosome Biogenesis

Making ribosomes is intricate, highly regulated, and tightly orchestrated. We think when the transcribing of ribosomal DNA gets jammed, ubiquitin comes to the rescue.

Richardson, L. A., Reed, B. J., Charette, J. M., Freed, E. F., Fredrickson, E. K., Locke, M. N., Baserga, S. J., R. G. Gardner. 2012.

A Conserved Deubiquitinating Enzyme Controls Cell Growth by Regulating
RNA Polymerase I Stability.

Cell Reports 2:372-385.

 

Abstract

PDF (2.3MB)

 

 

Reed, B.J., Locke, M.N., and R.G. Gardner. 2015.

A Conserved Deubiquitinating Enzyme Uses Intrinsically Disordered Regions to Scaffold Multiple Protein Interaction Sites.

Journal of Biological Chemistry 290:20601–20612.

 

Abstract

PDF (3.6MB)

More to come.

 

RESEARCH

A conserved deubiquitinating enzyme uses intrinsic disordered regions to scaffold multiple protein-interaction sites. JBC 290: 20601-20612.

Dynamic sumoylation of a conserved transcription corepressor prevents persistent inclusion formation during hyperosmotic stress. PLoS Genetics 12: e1005809.

OUR FUNDING

© 2020  Gardner Lab. All Rights Reserved

Richard Gardner

Department of Pharmacology

Box 357280

University of Washington

Seattle, WA 98195-7280