Systems biology explores the concept that every cell is made up of self-organizing, dynamic networks of proteins and genes, rather than individual components working in relative isolation. Ubiquitin is a protein that modifies or alters properties and functions of other proteins in cells.

Welcome to Gardner Lab

Thank you for stopping by to learn who we are and what we do! We are located in the Department of Pharmacology at the University of Washington in Seattle. We're part of the Molecular and Cellular Biology Graduate Program, the Neurobiology and Behavior Graduate Program, the Medical Science Training Program, and the Graduate Program in the Department of Pharmacology.

 

How I learned to embrace yeast infections

We're generally interested in how the cell regulates protein function through post-translational modifications. Such modifications are critical to the cell because, once a protein is made, the cell must be able to control the level of activity to balance it with need. Of the various known protein modifications, we're very interested in exploring how the small protein ubiquitin is used as a modifier of other proteins to alter their stability, enzymatic activity, interactions, localization, or other functions.

MEET THE PEOPLE

At Gardner Lab, diversity enhances our questing spirit.

Oh. My. Science.

it is an intriguing facet of biology that one protein is used to modify the behavior of another, although such a moiety most likely brings an added level of complexity that cannot be achieved by small molecule adapters. Out of this class, ubiquitin is one of the most fascinating because it is employed by the cell with such dramatic depth and breadth that it would appear no cellular process is left untouched by it.

READ ABOUT THE SCIENCE

Breakthroughs upon breakthroughs

Ubiquitin research is having a profound impact on the curing and preventing of diseases such as Alzheimer's, Cancer, and Multiple Sclerosis.

OUR FUNDING

  • How do I become a researcher or technician at Gardner Lab?

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  • What sort of bribes does Richard Garder accept?

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  • Where can I download the latest research?

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HAVE A PASSION
FOR SCIENCE?

That's what we're looking for at Gardner Lab. People who are seekers of answers, who are willing to do the work to find out how nature works. Our research has potential benefits in so many areas, and those involved have gone on to distinction in a wide variety of careers in pharmacology, cellular biology, and medical science.

CONTACT GARDNER LAB

RESEARCH

Gallagher, P. S., Clowes Candadai, S. V., and R. G. Gardner. 2014. The requirement for Cdc48/p97 in nuclear protein quality control degradation depends on the substrate and correlates with substrate insolubility.

Journal of Cell Science 127:1980-1991.

Gallagher, P. S., Oeser, M. L., Ayelet-chen, A., Kaganovich, D.,and R. G. Gardner. 2014. Cellular maintenance of nuclear protein  homeostasis.

Cellular and Molecular Life Sciences 71:1865-1879.

OUR FUNDING

© 2018  Gardner Lab. All Rights Reserved

QUICK LINKS

Richard Gardner

Department of Pharmacology

Box 357280

University of Washington

Seattle, WA 98195-7280