UBIQUITIN ROCKS OUR WORLD
Systems biology explores the concept that every cell is made up of self-organizing, dynamic networks of proteins and genes, rather than individual components working in relative isolation. Ubiquitin is a protein that modifies or alters properties and functions of other proteins in cells.
Welcome to Gardner Lab
Richard Gardner, Ph.D.
The Man, the Legend
In 2012 Richard Gardner, founder of Gardner Lab became an Associate Professor of Pharmacology at the University of Washington...
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Ubiquitin—Nature's Cellular Garbage Collector
We're generally interested in how the cell regulates protein function through post-translational modifications. Such modifications are critical to the cell because, once a protein is made, the cell must
be able to control the level of activity to balance it with need...
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Say Hello to Our Little Buddy: Saccharomyces Cerevisiae
Saccharomyces cerevisiae, or budding yeast, is what we use in the lab. Yeast has simple elegance, yet surprising biological complexity. Yeast has captivated generations of researchers who've used this intoxicating single-celled organism to open windows into the molecular
underpinnings of life...
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Therapy Cat Visits the Lab: Leaves Biohazard
I guess we don't get out much, because when BiBi the cat came for a visit, everyone was enchanted. Shy at first, he eventually warmed up to us and soon had the run of the Lab...
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Check Out What's Under the Hood at UW...
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A Little Help from Future Scientists Visiting the Lab
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Thank you for stopping by to learn who we are and what we do! We are located in the Department of Pharmacology at the University of Washington in Seattle. We're part of the Molecular and Cellular Biology Graduate Program, the Neurobiology and Behavior Graduate Program, the Medical Science Training Program, and the Graduate Program in the Department of Pharmacology.
How I learned to embrace yeast infections
We're generally interested in how the cell regulates protein function through post-translational modifications. Such modifications are critical to the cell because, once a protein is made, the cell must be able to control the level of activity to balance it with need. Of the various known protein modifications, we're very interested in exploring how the small protein ubiquitin is used as a modifier of other proteins to alter their stability, enzymatic activity, interactions, localization, or other functions.
MEET THE PEOPLE
At Gardner Lab, diversity enhances our questing spirit.
Oh. My. Science.
it is an intriguing facet of biology that one protein is used to modify the behavior of another, although such a moiety most likely brings an added level of complexity that cannot be achieved by small molecule adapters. Out of this class, ubiquitin is one of the most fascinating because it is employed by the cell with such dramatic depth and breadth that it would appear no cellular process is left untouched by it.
READ ABOUT THE SCIENCE
Breakthroughs upon breakthroughs
Ubiquitin research is having a profound impact on the curing and preventing of diseases such as Alzheimer's, Cancer, and Multiple Sclerosis.
OUR FUNDING
Accordion text 1 Proin dapibus dignissim felis sit amet varius. Duis eleifend eleifend ante, eu bibendum metus elementum et. Maecenas lacinia ante eu congue convallis. Pellentesque nec dapibus turpis. Sed vitae urna volutpat, ornare sapien quis, dapibus tortor. Curabitur sit amet semper odio, id pretium leo. Proin imperdiet aliquam nisi.
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Phasellus tempus felis ut odio condimentum aliquam. Nam ut lorem commodo, molestie erat eu, feugiat nisi. Curabitur sed mauris magna. Mauris porta enim tempor vehicula tincidunt. Quisque pellentesque sem ut diam vestibulum pretium. Fusce mattis metus a eros laoreet, eu interdum tellus ornare.
Accordion Text 3 Proin dapibus dignissim felis sit amet varius. Duis eleifend eleifend ante, eu bibendum metus elementum et. Maecenas lacinia ante eu congue convallis. Pellentesque nec dapibus turpis. Sed vitae urna volutpat, ornare sapien quis, dapibus tortor. Curabitur sit amet semper odio, id pretium leo. Proin imperdiet aliquam nisi.
Phasellus tempus felis ut odio condimentum aliquam. Nam ut lorem commodo, molestie erat eu, feugiat nisi. Curabitur sed mauris magna. Mauris porta enim tempor vehicula tincidunt. Quisque pellentesque sem ut diam vestibulum pretium. Fusce mattis metus a eros laoreet, eu interdum tellus ornare.
HAVE A PASSION
FOR SCIENCE?
That's what we're looking for at Gardner Lab. People who are seekers of answers, who are willing to do the work to find out how nature works. Our research has potential benefits in so many areas, and those involved have gone on to distinction in a wide variety of careers in pharmacology, cellular biology, and medical science.
CONTACT GARDNER LAB
RESEARCH
Gallagher, P. S., Clowes Candadai, S. V., and R. G. Gardner. 2014. The requirement for Cdc48/p97 in nuclear protein quality control degradation depends on the substrate and correlates with substrate insolubility.
Journal of Cell Science 127:1980-1991.
Gallagher, P. S., Oeser, M. L., Ayelet-chen, A., Kaganovich, D.,and R. G. Gardner. 2014. Cellular maintenance of nuclear protein homeostasis.
Cellular and Molecular Life Sciences 71:1865-1879.
OUR FUNDING
© 2018 Gardner Lab. All Rights Reserved
QUICK LINKS
Richard Gardner. The Man. The Legend...
In 2012 Richard Gardner, founder of Gardner Lab became an Associate Professor of Pharmacology at the University of Washington...
READ MORE
Ubiquitin—Nature's Cellular Garbage Collector
We're generally interested in how the cell regulates protein function through post-translational modifications. Such modifications are critical to the cell because, once a protein is made, the cell must be able to control the level of activity to balance it with need...
READ MORE
3D animation from novice to expert: After Effects CC
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Adobe Premiere Pro: Video editing like a professional
Donec ante diam, luctus congue turpis id, faucibus rutrum magna. Cras nisl odio, ornare quis nibh sit amet, pulvinar consectetur metus Praesent porttitor, mauris non gravida suscipit...
READ MORE
Check Out What's Under the Hood at UW...
Donec ante diam, luctus congue turpis id, faucibus rutrum magna. Cras nisl odio, ornare quis nibh sit amet, pulvinar consectetur metus Praesent porttitor, mauris non gravida suscipit...
READ MORE
A Little Help from Future Scientists Visiting the Lab
Donec ante diam, luctus congue turpis id, faucibus rutrum magna. Cras nisl odio, ornare quis nibh sit amet, pulvinar consectetur metus Praesent porttitor, mauris non gravida suscipit...
READ MORE