SCIENCE
At Garder Lab, it's real-world science, done by real-world scientists. The modern scientist is much more than a lab coat. It's a person questing for scientific truths which have a significant impact on actual lives, health, and learning.
BROWSE THE SCIENCE
What do we do?
At Gardner Lab, we're all about the science. Below you'll find our latest research, plus some material that helps explain some of the questions we're trying to answer, gathered from our archives and the internet.
Amanda Bradley's Research
Like a ‘flash mob’, Amanda’s work in stress looks at the transient coordination of proteins that allow the cell to adapt...
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Nicole Marsh's Research
Understanding stress coordination is like putting the pieces of a puzzle together. Nicole is intrigued how the transcriptional puzzle during stress is put together...
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Tim Mackie's Research
We all know stress accumulates with age. Tim is interested in how stress pathways operate in youth and how they change with age...
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Heather Borror's Research
Proteins fold into structural origami. But, their delicate structure can become crumpled at any time. Heather’s research explores how the cell manages structural misfolding....
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Katie Mostoller's Research
How the brain functions and what goes wrong is something I am intensely interested in. My research focuses on understanding how protein aggregates affect cell function...
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Rich Gardner's Research
I am interested in how organisms manage stress. I would love to use tardigrades, hydras, or other organisms that are ageless to understand stress and age...
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Gardner Lab's Publications
We are flexing our minds to expand our understanding of the role for ubiquitin and ubiquitin-like modifiers within the nucleus. We are particularly interested in protein quality control, chromatin-associated processes, and ribosome biogenesis...
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Nuclear Armageddon
Proteins govern nuclear functions. If they lose their structures, the nucleus can become critical. We are interested in how the cell protects against protein misfolding armageddon...
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Wrestling with Stress
Cells are constantly grappling with stress. We are interested in the roles protein sumoylation plays in stress responses, especially at the transcriptional level...
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The Traffic Jam of Ribosome Biogenesis
Making ribosomes is intricate, highly regulated, and tightly orchestrated. We think when the transcribing of ribosomal DNA gets jammed, ubiquitin comes to the rescue...
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Disorder: the Dark Matter of the Protein World
Proteins are typically imagined as having defined 3D structures. But ~30% of proteins are disordered and conformationally flexible. We are interested in how disorder confers protein function...
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Shining Light on Nuclear Dysfunction
How the nucleus functions, and what goes awry in disease, is one of our primary interests. A spotlight for the lab is nuclear physiology....
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Congratulations, Dr. Kamran
Sabrina conducted her studies on the ubiquitin-mediated regulation of rDNA transcription. Sabrina defended her dissertation on December 6, 2018. Great job Dr. Kamran!
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Congratulations, Dr. Enam
Charisma conducted her studies on how key cofactors for the Cdc48 segregase work in nuclear protein quality control. Charisma defended her dissertation on August 3, 2018. Awesome job Dr. Enam!
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Congratulations, Dr. Nadel
Cory defended his dissertation on June 1, 2018. Superb job Dr. Nadel!Cory was interested in how the key osmolyte glycerol modulates phase transitions during osmotic stress.
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NSF-BSF Grant Awarded to Gardner Lab
The NSF-BSF award is to understand what different nuclear protein quality control systems recognize in their misfolded protein substrates...
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National Institutes of Health Awards Gardner Lab
This NIH award is to explore the mechanisms of how the Cyc8-Tup1 complex is dynamically sumoylated during hyperosmotic stress...
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Congratulations, Dr. Jones
Ramon studied the variability of chaperones in nuclear protein quality control degradation, Ramon defended his dissertation on June 9, 20178. Great job Dr. Jones!
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RESEARCH
A conserved deubiquitinating enzyme uses intrinsic disordered regions to scaffold multiple protein-interaction sites. JBC 290: 20601-20612.
Dynamic sumoylation of a conserved transcription corepressor prevents persistent inclusion formation during hyperosmotic stress. PLoS Genetics 12: e1005809.
OUR FUNDING
© 2020 Gardner Lab. All Rights Reserved
QUICK LINKS
Richard Gardner
Department of Pharmacology
Box 357280
University of Washington
Seattle, WA 98195-7280